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Troponin I Antibodies for IVD Use

Troponin monoclonal antibody #B9085MA06-MA:

• is specific to the N-terminus of human cardiac troponin I (HcTnI).
• recognizes amino acids 24-40 of HcTnI.
• recognizes the free form of HcTnI and the complexed form of HcTnI.
• does not cross react with skeletal troponin, troponin C or troponin T.

Human cardiac Troponin I (HcTnI) is a specific diagnostic marker of acute myocardial infarction. Other troponin subunits are less specific. For example, troponin T is elevated in patients with renal failure, pneumonia, diabetes mellitus or certain systemic illnesses making troponin T a non-specific diagnostic marker.

An antibody recognizing both free HcTnI and complexed HcTnI is ideal since the molecular forms of HcTnI in serum are not precisely defined. HcTnI may be in free form or complexed with other troponin subunits. Cross-reactivity of antibodies with skeletal troponin I is avoided by antibodies recognizing the 31 amino acid residues on the N-terminus of HcTnI that are not present on the skeletal troponin I. The N-terminus of HcTnI is also more resistant to degradation than other portions of the I subunit.

Other monoclonal antibodies and polyclonal antibodies to HcTnI are available. These antibodies may complement antibody #B9085MA06-MA in your assay format, resulting in suitable matched-pair reagents.

To order this antibody or for more information, click here.

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